CRSwNP and severe eosinophilic asthma (SEA) share a common type 2 inflammatory pathway driven by eosinophils, reflecting the concept of united airway disease. Anti-IL-5 therapies target eosinophilic inflammation and offer a promising strategy for managing patients with both upper and lower airway involvement. This session will review the role of IL-5 in eosinophilic airway disease and discuss clinical experiences in optimizing treatment for patients with CRSwNP and SEA.