Background: Impact
•Multiple gram-negative pathogens
–such as Pseudomonas aeruginosa and Acinetobacter spp are resistant to many routinely prescribed anti-infective agents
•Gram-positive organisms, Staphylococcus aureus is the leading pathogen of concern
•S aureus
–The most frequent cause of hospital-acquired pneumonia
–a leading cause of catheter-related bloodstream infections
• methicillin-resistant S aureus (MRSA) challenges critical care physicians daily.